Chemistry (PhD)

2019-20 (also available for 2020-21)

This course is eligible for Doctoral loan funding. Find out more.

Start date

23 September 2019

13 January 2020

20 April 2020

Duration

The maximum duration for a full-time PhD is 3 years (36 months) with an optional submission pending (writing up period) of 12 months.

Sometimes it may be possible to mix periods of both full-time and part-time study.

Application deadlines

For PGR start date January 2020

29 November 2019

For PGR start date April 2020

11 February 2020

For PGR start date September 2020

02 July 2020

About the research degree

A PhD is the highest academic award for which a student can be registered.This programme allows you to explore and pursue a research project built around a substantial piece of work, which has to show evidence of original contribution to knowledge.

A full-time PhD is a three year full-time programme of research and culminates in the production of a large-scale piece of written work in the form of a research thesis that should not normally exceed 80,000 words.

Completing a PhD can give you a great sense of personal achievement and help you develop a high level of transferable skills which will be useful in your subsequent career, as well as contributing to the development of knowledge in your chosen field.

You are expected to work to an approved programme of work including appropriate programmes of postgraduate study (which may be drawn from parts of existing postgraduate courses, final year degree programmes, conferences, seminars, masterclasses, guided reading or a combination of study methods).

You will be appointed a main supervisor who will normally be part of a supervisory team, comprising up to three members to advise and support you on your project.

Entry requirements

The normal level of attainment required for entry is:

  • a Master's degree from a UK University or equivalent, in a discipline appropriate to the proposed programme to be followed, or
  • an upper second class honours degree (2:1) from a UK university in a discipline appropriate to that of the proposed programme to be followed, or
  • appropriate research or professional experience at postgraduate level, which has resulted in published work, written reports or other appropriate evidence of accomplishment.

If your first language is not English, you will need to meet the minimum requirements of an English Language qualification. The minimum for IELTS is 6.0 overall with the written element at least 6.0 with no element lower than 5.5, or equivalent will be considered acceptable. Read more about the University’s entry requirements for students outside of the UK on our Where are you from information pages.

What can I research?

There are several research topics available for this degree. See below examples of research areas including an outline of the topics, the supervisor, funding information and eligibility criteria:

Outline

Probiotic bacteria produce polysaccharides that they release into the environment. Many of these polysaccharides have desirable biological and chemical activity. This research programme will use the tools of analytical science to determine the structures of these polysaccharides. Students will be trained in the use of NMR spectroscopy and mass spectrometry.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Small organic molecules are important in drug discovery and in novel materials research. The development of sustainable syntheses to these compounds using small organic molecules as catalysts is an important area of research. The aim of this project is to develop new iodoarene catalysts, especially chiral variants, and investigate their utility in the formation of small organic molecules.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

The project will develop synthetic routes to novel bridged bicyclic amines, non-racemic three-dimensional drug-like scaffolds, using flexible and scalable catalysis. It will extend chemistry we have previously reported in Chem. Commun. 2012, 48, 4836 and Chem. Commun. 2013, 49, 8931.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6.000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Antimicrobial resistance (AMR) increasingly threatens our health and well-being, as infectious microbes evolve to become resistant to existing antibiotics. There is an ongoing need to discover new antibiotic classes and bring them to the clinic. The Minor Groove Binder (MGB) drug discovery platform of the Universities of Strathclyde and Huddersfield contains a family of novel compounds one of which, MGB-BP-3, is ready to enter Phase II Clinical Trial for the treatment of Clostridium difficile, in partnership with our developers MGB Biopharma.1 MGBs kill bacteria through binding to their DNA and interrupting essential bacterial metabolism, but importantly, they act at a number of targets within each cell, which means that variants that are resistant to MGBs have not been seen.2,3 We wish to investigate a range of new compounds from the MGB portfolio as potential agents for clinically challenging infections, principally those of the ESKAPE pathogen set, in addition to exploring their capacity to synergise with existing antibiotics.4,5 Beyond this, we are also interest in performing hit to lead optimisation in the antifungal, antimycobacterial and antiparasitic fields.

In a pilot study, we have already shown that in situations where a clinical pathogen has developed resistance to an existing antibiotic, dual therapy with an MGB may extend the effective lifetime of that antibiotic. This would ‘repurpose’ that ailing clinical antibiotic and extend its useful lifetime.

At present, there are a number of interesting avenues of both Chemistry and Biology research, which we wish to evaluate:

Chemistry 1. Design of novel antifungal MGBs 2. Design of novel antimycobacterial MGBs, particularly for TB. 3. Design of novel antiparasitic MGBs. 4. Design of novel antibacterial MGBs effective against Gram-negative pathogens. 5. Investigation of MGB physicochemical property modulation on activity profile against various pathogenic organisms.

Biology 1. Investigation of MGB synergy with a range of clinically relevant antibiotics. 2. Investigation of MGB synergy with a range of efflux pump inhibitors. 3. Investigation of MGB synergy with other MGBs. 4. Investigation of mechanism of action of novel MGBs that are exiting our current synthetic medicinal chemistry pipeline.

This project provides students with the opportunity to contribute to our Global MGB Drug Development efforts, and assist with developing a better understanding of our emerging new class of antibiotic.

References 1 http://www.mgb-biopharma.com/mgb-biopharma-successfully-completes-phase-i-clinical-trial-with-oral-mgb-bp-3-a-truly-novel-antibiotic-targeting-clostridium-difficile-infections/ https://clinicaltrials.gov/ct2/show/NCT02518607?term=mgb&rank=1 2 F. J. Scott et al., Eur J Med Chem. 2017 Aug 18;136:561-572. 3 F. J. Scott et al., Euro. J. Med. Chem., 2016, 116, 116–125. 4 F. J. Scott et al., Bioorg. Med. Chem. Lett., 2016, 26, 3478-86. 5 F. J. Scott et al., Bioorg. Med. Chem Lett., 2016, 26, 3326-3329.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of between £3-£15,000 per annum are required depending on the nature of the project.

Deadline

Home/EU – for September- June 30th, for January-October 31st and Overseas for September- May 31st, for January- September 30th

Supervisors

How to apply

Outline

Nuclear Magnetic Resonance (NMR) is an incredibly powerful and versatile analytical technique. Providing structural and dynamic information at the atomic level NMR is ubiquitous within the physical sciences but development of new applications, or even routine exploitation in the case of volume limited samples, is hindered by low intrinsic sensitivity. NMR sensitivity can be boosted by transferring ‘spin polarization’ from unpaired electrons. Whilst such transfer has conventionally been achieved using microwave pumping of electronic transitions in so-called dynamic nuclear polarization (DNP) experiments, there are major technical challenges to this approach. Recently we have demonstrated a method using optical excitation instead of microwave irradiation. This not only overcomes a number of technical challenges, but also potentially offers much higher sensitivity gains above the maximum possible in microwave DNP. This PhD project will build upon the recent proof of principle demonstration of optically pumped DNP, investigating multiple factors such as illumination time, illumination wavelength, magnetic field strength and choice of polarizing agent. The theory underpinning the technique will also be tested and new numerical models devised. This will allow development of the methodology from proof of principle to real-world application.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

This project involves the combination of thermal analysis and ambient ionisation mass spectrometry (specifically, DART-MS). A new integrated system has been developed that allows for investigation of the behaviour of complex materials as a function of temperature. The successful candidate will further develop and refine the system and investigate its wide-ranging applications.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £3,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Complexes of metals such as Ru(II), Ir(III), Re(I) etc have attracted enormous interest in the literature due to their intriguing and attractive photophysical properties. Our group has paid particular attention to the study of complexes bearing 1,2,3-triazole based ligands and have reported encouraging results on their use as cellular imaging probes and singlet oxygen sensitisation. These complexes therefore have potential applicability as dual-mode theranostic agents. The project will therefore involve the synthesis and characterisation of new luminescent complexes and their optimisation for cellular imaging and photodynamic therapy.

See the following publications from our group at https://www.hud.ac.uk/ourstaff/profile/index.php?staffid=222

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

The nature of fabric manufacture can cause fabric producers to enforce long lead times and large minimum orders on their customers, making it difficult to produce bespoke fabrics in limited quantities. The research programme will be directed at materials development in one or more of the following areas: polymer development, textile functionalisation, and stratified fabric production. In addition to process development and characterisation, this project will design new or adapt existing fabric manufacturing processes and establish underpinning structure-property relationships.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of between £3-£15,000 per annum are required depending on the nature of the project.

Deadline

Home/EU – for September- June 30th, for January-October 31st and Overseas for September- May 31st, for January- September 30th

Supervisors

How to apply

Outline

In this project novel polysaccharides will be identified, purified, fully characterised. One major concern is that a large amount of work has previously been carried out on crude material and not on highly purified or well characterised polysaccharide components which makes conclusions on functionality difficult.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

In comparison to traditional composite materials, nanocomposites exhibit enhanced properties through the incorporation of nanofillers. Polymer-based nanocomposites combine the benefits of polymers, such as low cost and ease of processing, with the unique features of the nanomaterials, such as high surface to volume ratio, high aspect ratio, excellent toughness and strength and improved electrical and thermal conductivities. In the last few years, polymer nanocomposites with enhanced optical, mechanical, electrical and thermal properties have been developed. A key challenge for nanocomposites is to prevent agglomeration of the nanofillers, in order to optimise property enhancement. Potential applications of nanocomposites include aerospace, automotive, marine, sports materials, construction, structures, electrical and electronic systems, biomedical devices, thermal management systems, adhesives, paints and coatings, industrial tooling and other general consumer products. In parallel with these developments, the discovery of graphene has been heralded as a game-changer for many areas of science and engineering, including materials science. The power of graphene is that it combines a range of exceptional properties in one material. A key challenge for promoting practical applications of graphene is to translate these properties into macro-structured materials. Putting these two concepts together, graphene-polymer nanocomposites utilise graphene as the nanofiller such that they combine the benefits of nanocomposites with the unique properties of graphene. Further to this, the synergistic effect of incorporating two or more nanofillers to form ‘hybridised nanocomposites’ has also been proposed for additional enhancement of properties. For example, the remarkable synergetic effect between graphene platelets and multiwalled carbon nanotubes has been observed to greatly improve the mechanical properties and thermal conductivity of nanocomposites. However, graphene-polymer and hybridised nanocomposites are at an early stage of development and their properties and behaviour are not fully understood. As such, there is great scope for further work and exploitation of these materials. This project will examine the processing of a range of graphene-polymer nanocomposites, test mechanical properties, assess thermal stability and examine breakage characteristics, in order to understand and optimise the behaviour of these materials.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Autoxidation is one of the main mechanisms of oxidative degradation of active pharmaceutical ingredients (APIs). It can result in a reduced shelf life for a pharmaceutical product, the need for low temperature storage and shipments or the inclusion of antioxidants in a formulation. When a new API enters development understanding the risk of autoxidation is therefore crucial. The autoxidation mechanism is well-known; an initially formed radical combines with oxygen from air to form a peroxyl radical. The peroxyl radical can then abstract any weakly bound hydrogen atom, to generate a new radical that can propagate the chain reaction. In principle, the chain reaction can be fast as long as the breaking CH bond is weaker than the OH bond that is formed in the hydrogen transfer. The CH bond dissociation energy can be accurately calculated for a hydrogen atom in any molecule and if autoxidation occurs these values are very good at predicting the site at which it will occur. However, the absolute value is not the sole predictor of whether autoxidation occurs at all. The ability of the chain mechanism to propagate seems key, with the subsequent formation of both carbon based and oxygen based radicals. Electron Paramagnetic Resonance (EPR) spectroscopy is a powerful tool for studying free radical formation and as such can be used to investigate autoxidative degradation mechanisms in APIs. Building on previous work in which EPR was validated as a tool for non-destructive investigation of the extent of API oxidation in this PhD project EPR will be used to investigate the factors allowing autoxidation reactions to propagate, and ways in which autoxidation can be prevented.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Complexes of metals such as Ru(II), Ir(III), Re(I) etc have attracted enormous interest in the literature due to their intriguing and attractive photophysical properties. Our group has paid particular attention to the study of complexes bearing 1,2,3-triazole based ligands and have shown in these systems highly novel photochemical reactivity. This project will involve the synthesis and characterisation of new triazole-based complexes and their detailed spectroscopic and theoretical investigation in order to elucidate the mechanism of their photochemical reactivity.

See the following publications from our group at https://www.hud.ac.uk/ourstaff/profile/index.php?staffid=222

Funding

There is currently no funding for this project and we encourage interested self-funding students to apply. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Textile wet processing is currently an important aspect of textile production as it adds value to the textiles by improving aesthetics, comfort and functional properties. However, wet processing consumes substantial volumes of water and chemicals, which frequently have associated health and/or environmental hazards, and subsequently produce high quantities of effluent requiring expensive dilution and/or treatment. This research will investigate alternative dry finishing processes that can offer lower costs, reduced environmental impact, and the potential to produce new products with improved performance. This research will incorporate materials development in one or more of the following areas: polymer development, colouration of textiles, textile functionalisation, and plasma treatment.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of between £3-£15,000 per annum are required depending on the nature of the project.

Deadline

Home/EU – for September- June 30th, for January-October 31st and Overseas for September- May 31st, for January- September 30th

Supervisors

How to apply

Outline

Complexes of metals such as Ru(II), Ir(III), Re(I) etc have attracted enormous interest in the literature due to their intriguing and attractive photophysical properties. Our group has paid particular attention to the study of complexes bearing 1,2,3-triazole based ligands and have shown these systems to have fascinatingly diverse properties from intense luminescent emission to highly novel photochemical reactivity. Such complexes therefore present potential applications in areas of materials science, biological luminescent imaging and in photodynamic molecular medicines. The project will therefore involve the synthesis and thorough photophysical characterisation of a series of triazole-based complexes and assessment for these potential applications.

See the following publications from our group

Labilising the ‘photoinert’: extraordinarily facile photochemical ligand ejection in a [Os(N^N)3]2+ complex
Paul A. Scattergood, Daniel A. W. Ross, Craig R. Rice and Paul I. P. Elliott
Angewandte Chemie International Edition, 2016, 55, 10697–10701

Photochemistry of [Ru(pytz)(btz)2]2+ and characterisation of a κ1-btz ligand-loss intermediate
Paul A. Scattergood, Usman Khushnood, Amina Tariq, David J. Cooke, Craig R. Rice and Paul I.P. Elliott
Inorganic Chemistry, 2016, 55, 7787-7796

Luminescent osmium(II) bi-1,2,3-triazol-4-yl complexes: photophysical characterisation and application in light-emitting electrochemical cells
Daniel A. W. Ross, Paul A. Scattergood, Azin Babaei, Antonio Pertegás, Henk J. Bolink and Paul I. P. Elliott
Dalton Transactions, 2016, 45, 7748-7757

Photochemistry of Ru(II) 4,4’-bi-1,2,3-triazolyl (btz) complexes: Crystallographic characterization of the photoreactive ligand loss intermediate trans-[Ru(bpy)(κ2-btz)(κ1-btz)(NCMe)]2+
Christine E. Welby, Georgina K. Armitage, Harry Bartley, Aaron Wilkinson, Alessandro Sinopoli, Baljinder S. Uppal, Craig R. Rice and Paul I. P. Elliott
Chemistry – A European Journal, 2014, 20, 8467-8476

Photochemical ligand ejection from non-sterically promoted Ru(II)bis(diimine) 4,4'-bi-1,2,3-triazolyl complexes
Christine E. Welby, Georgina K. Armitage, Harry Bartley, Alessandro Sinopoli, Baljinder S. Uppal and Paul I. P. Elliott
Photochemical Photobiological Sciences, 2014,13, 735-738

Unambiguous characterisation of a photoreactive ligand loss intermediate
Christine E. Welby, Craig R. Rice and Paul I. P. Elliott
Angewandte Chemie International Edition, 2013, 52, 10826-10829

Luminescent biscyclometalated arylpyridine iridium(III) complexes with 4,4’-bi-1,2,3-triazolyl ancillary ligands
Christine E. Welby, Luke Gilmartin, Ryan R. Marriott, Adam Zahid, Craig R. Rice, Elizabeth A. Gibson and Paul I. P. Elliott
Dalton Transactions, 2013, 42, 13527

Synthesis, characterisation and theoretical study of ruthenium 4,4'-bi-1,2,3-triazolyl complexes: fundamental switching of the nature of S1 and T1 states from MLCT to MC
Christine E. Welby, Stev Grkinic, Adam Zahid, Baljinder S. Uppal, Elizabeth A. Gibson, Craig R. Rice and Paul I. P. Elliott
Dalton Transactions, 2012, 41, 7637.

Funding

There is currently no funding for this project and we encourage interested self-funding students to apply. In addition to tuition fees, bench fees of £5,000 per annum are also required.

Deadline

Supervisors

How to apply

Outline

A civil engineer cannot design architectural structures without knowing the mechanical properties of the building materials being used. Similarly, scientists and engineers require access to physical properties of chemicals to design and validate experiments and industrial processes. Physical properties depend on the nature of molecules of the substance. The ultimate generalisation of physical properties requires a complete understanding of molecular behaviour, which we do not have yet. Reliable physical property data estimation is important for a range of applications. These include the design of industrial processes, computer-aided molecular design, prediction of physicochemical properties for regulatory purposes, toxicity prediction, and determining the properties of substances for which direct measurement is difficult or impossible. There are a number of approaches to property estimation and prediction, including using the law of corresponding states, empirical data fitting, first order approximations using group contributions, quantitative structure-property relationships (QSPRs), statistical mechanics, and molecular modelling. However, many existing approaches fall down on a number of counts. Weaknesses include: replying on data collected under varying conditions or with different protocols; undefined ranges of applicability; use of imprecise data; repetition of data from the same compound within the training and/or validation dataset; inadequate or misinterpretation of statistics; inadequate and/or undisclosed dataset; and failure to validate correctly. This project will combine the power of experimental measurements with data analysis and computation modelling. It is expected that the triangulation and cross-validation of these approaches will allow us to greatly advance physical property estimation and prediction methodologies.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

The purification of systems that exhibit azeotropic behaviour is a key challenge for many industrial processes. Various approaches to solving this challenge have been explored since the late 1920s. One such approach is pressure swing distillation (PSD). This method utilizes the pressure sensitivity of some binary azeotropes to shift the azeotropic composition of the mixture. Another, more common method that has been used since the 1920s is extractive distillation (ED). This method involves adding a third component called an entrainer to a binary mixture creating a ternary mixture. This method is becoming increasingly unpopular due to the restriction of solvent uses by environmental health and safety commissions world-wide, and it may continue to become more unpopular due to increase in global demand for reduced energy usage and CO2 emissions. As such it is imperative to better understand both approaches, to examine how they can be improved and to explore alternative solutions. For example, various PSD studies exist, however, these only scratched the surface of PSD development; this might be due in part to a lack of interest from industry or the prevalence of previous work into ED systems. These works, along with others have shown that PSD can have numerous benefits over more contemporary methods if built and utilized to full optimization. PSD could become more widely used, however, further work is needed to unlock the full potential of this methodology. Furthermore, the identification and study of greener solvents for use as entrainers in ED is a very underdeveloped area. In addition, alternative/novel methods for azeotrope purification are lacking and the reasons for an absence of innovation in this area is unclear. This project will utilise process simulation in order to examine the optimisation of existing approaches to azeotropic distillation, to identify and test more environmentally friendly entrainers for ED and to explore the feasibility of novel methods for azeotrope purification.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £3.000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

The processing of cellulose in the production of polymeric materials by industry generates very significant amounts of waste products. Amongst these are a group of molecules that are called saccharinic acids. Saccharinic acids are potentially valuable platform chemicals and can be converted into a number of activated substrates that can be used as starting materials by the fine chemical industry. A number of projects are looking at developing potential applications for saccharinic acids in organic synthesis and a range of protecting group and activation chemistries are being explored. We are looking to start a programme of work to determine if these molecules can be employed in the production of polymers.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Graphene has been heralded as a “wonder material” and is among a number of recently discovered carbon allotropes that demonstrate outstanding and versatile properties. Chemical vapour deposition (CVD) is a powerful and flexible technique for creating single- and multilayer-graphene and carbon nanotubes. These new materials exhibit a variety of unique and tuneable optical, electronic, mechanical, structural, thermal and chemical properties, offering the prospect of applications in photovoltaics, nanoelectronics, sensors, display technology, nanocomposites, simulated photosynthesis, batteries and supercapacitors. The aim of this project is to understand and optimise the CVD synthesis and graphene transfer/utilisation conditions on the final properties of graphene materials produced. This will involve examining the effect of substrate properties and processing conditions on the graphene material morphological and physical properties. The optimisation of these properties and parameters will lead to new materials with “super”-properties, making them suitable to fulfil a range of unmet industrial needs. Potential applications include super-strong fibres, supercapacitors and superconductors.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

This research will be in the area of synthetic organic chemistry and will focus specifically on the synthesis of heterocyclic natural products. The targets of this project are the indolizidine and pyrrolizidine alkaloids. These systems are of interest in the possible treatment of various diseases such as cancer, diabetes and viral infections such as AIDS, and some of them have the potential to function as potent analgesics or as potential treatments for Alzheimer’s disease and other neurological disorders. Examples of such compounds include the well-known "poison frog alkaloids".

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

This topic is in the area of synthetic organic chemistry used to target heterocyclic products with medicinal applications. The heterocyclic targets include pyrrolo-fused natural products such as the pyrrolobenzodiazepines and their sulfur analogues, beta-sultams, homotropanes, isoflavones, oxadiazoles and aza-sugars. The biological activities that we are interested in include anti-tumour compounds, antibiotics and anti-inflammatory compounds that target diseases such as Alzheimer's.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of between £3-£15,000 per annum are required depending on the nature of the project.

Deadline

Home/EU – for September- June 30th, for January-October 31st and Overseas for September- May 31st, for January- September 30th

Supervisors

How to apply

Outline

We are involved in research programmes with cancer biologists that require the preparation of novel molecules for testing. This includes the development of synthetic methodology to prepare potential drugs containing fluorescent tags and antibody conjugates.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £xx per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

Silicon is the second most abundant element on Earth however its synthetic chemistry has been little studied compared to its close neighbour carbon. The aim of this project is to develop new synthetic methods to access silicon heterocycles. These types of compounds are becoming of increasing interest in drug discovery.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £6,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

Outline

The mechanisms of a large number of reactions that are undertaken each day, in both academic and industrial laboratories, are not fully understood. In this project a student will be trained in the use of the techniques of physical organic chemistry in order to explore the mechanisms of industrially relevant reactions. The work will focus on the development of processes for the synthesis of oligonucleotides.

Funding

Self-funding applicants are welcome. In addition to tuition fees, bench fees of £5,000 per annum are required.

Deadline

Home/EU -June 30th/October 31st and Overseas May 31st/September 30th

Supervisors

How to apply

All major areas of chemistry are covered with areas of strength including:

• synthetic organic chemistry • physical organic chemistry • carbohydrates, proteins and enzyme chemistry • organometallic and supramolecular chemistry • heterogeneous catalysis and adsorption • thermal methods of analysis and synthesis • materials chemistry

To find out more about the research we conduct, take a look at our Research, Innovation and Skills webpages, where you will find information on each research area. To find out about our staff visit ‘Our experts’ which features profiles of all our academic staff.

You will need to complete a research proposal outlining your areas of interest and when this is submitted along with your research degree application form we will look for the academics within the University who have the expertise and knowledge to supervise you and guide you through your research degree.

Research Enviroment

We provide a supportive and vibrant research environment for postgraduate researchers (PGRs). Researchers at all levels are encouraged to contribute and collaborate. The Graduate School ensures that postgraduate research is of the highest quality and equips you with the resources that you need to become a successful researcher.

We have an exciting and comprehensive Researcher Skills Development Programme available to all postgraduate researchers. This enables you to broaden your knowledge and access tools and skills which can significantly improve employability. The programme is also mapped onto Vitae’s Researcher Development Framework (RDF), allowing you to benefit from Vitae support as well as our own Programme.

We offer skills training through a programme designed to take advantage of technology platforms as well as face-to-face workshops and courses. The University has subscribed to Epigeum, a programme of on-line research training support designed and managed by staff at Imperial College London which will be accessed via Brightspace, the University’s Virtual Learning Environment. We also subscribe to the University of East Anglia webinar series and The Good Doctorate video training series. We are part of the North West and Yorkshire PGR Training Group that allows PGRs to attend relevant training opportunities at other nearby universities.

Student support

At the University of Huddersfield, you'll find support networks and services to help you get ahead in your studies and social life. Whether you study at undergraduate or postgraduate level, you'll soon discover that you're never far away from our dedicated staff and resources to help you to navigate through your personal student journey. Find out more about all our support services.

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The Office for Students (OfS) is the principal regulator for the University.